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Abstract #3151

Evolution of functional and structural connectivity of cognitive frontoparietal network during 2 years of fingolimod therapy of multiple sclerosis

Jian Lin1, Pallab Bhattacharyya1, Hong Li2, Ken Sakaie1, Robert Fox3, and Mark J Lowe1

1Radiology, Cleveland Clinic, Cleveland, OH, United States, 2Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States, 3Neurology, Cleveland Clinic, Cleveland, OH, United States

It has been reported that the cognitive impairment in MS is related to the dysfunction of frontoparietal network (FPN). In a longitudinal study of MS patients undergoing fingolimod treatment, we investigated the structural and function connectivity of FPN over 2 years. The trend of changes in functional connectivity MRI, and transverse diffusivity measured by DTI probabilistic tractography indicate that fingolimod treatment stabilized damage of structural and functional connectivity of FPN sometime around/after the 1st year of treatment similar to that reported for motor network.

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