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Abstract #3153

Functional connectivity correlates of altered intraindividual variability of processing speed in multiple sclerosis patients with young adult onset

Sindhuja T Govindarajan1, Gregory Bodik1, Yilin Liu1, Leigh Charvet2, Lauren Krupp2, and Timothy Duong1

1Radiology, Stony Brook University Medical Center, Stony Brook, NY, United States, 2Neurology, New York University Langone Medical Center, New York City, NY, United States

Intra-individual variability of processing speed (IIV-PS) is a more sensitive discriminator between controls and MS patients in early disease stage than the normative mean scores of PS. We used rsfMRI to interrogate the neural correlates of IIV-PS and means of PS in MS patients with young-adult onset. Significant correlation of the amplitude of low-frequency fluctuations (ALFF) was found with IIV-PS but not with mean PS. Seed-to-voxel functional connectivity analysis showed significant connections associated with altered IIV of identification task, but not the IIV of detection task. This approach identified the neural networks associated with altered IIV-PS in MS.

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