Abstract #3155

Individual simulation of brain functional reorganization in early multiple sclerosis - The Virtual Brain approach

Rebecca Marchetti¹, Bertrand Audoin², Marmaduke Woodmann³, Arnaud Le Troter¹, Paul Bartelemy¹, Manon Philibert¹, Pierre Besson¹, Jean Pelletier², Maxime Guye⁴, Viktor Jirsa³, and Jean-Philippe RANJEVA⁵

¹CEMEREM, CRMBM AMU CNRS, Marseille, France, ²Neurology, APHM, Marseille, France, ³INS AMU INSERM, Marseille, France, ⁴CEMEREM, APHM, Marseille, France, ⁵CRMBM AMU CNRS, Marseille, France

We demonstrate here that 'The Virtual Brain' (TVB), a computational neural mass model fed with structural connectome derived from individual diffusion MRI can successfully generate reorganized individual resting-state functional connectomes in early multiple sclerosis patients with similar topologies that those obtained with real rs-fMRI data. This opens new perspectives to predict and better understand the brain functional reorganization occuring in individual MS patients during disease progression or treatment.

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