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Abstract #3155

Individual simulation of brain functional reorganization in early multiple sclerosis - The Virtual Brain approach

Rebecca Marchetti1, Bertrand Audoin2, Marmaduke Woodmann3, Arnaud Le Troter1, Paul Bartelemy1, Manon Philibert1, Pierre Besson1, Jean Pelletier2, Maxime Guye4, Viktor Jirsa3, and Jean-Philippe RANJEVA5

1CEMEREM, CRMBM AMU CNRS, Marseille, France, 2Neurology, APHM, Marseille, France, 3INS AMU INSERM, Marseille, France, 4CEMEREM, APHM, Marseille, France, 5CRMBM AMU CNRS, Marseille, France

We demonstrate here that 'The Virtual Brain' (TVB), a computational neural mass model fed with structural connectome derived from individual diffusion MRI can successfully generate reorganized individual resting-state functional connectomes in early multiple sclerosis patients with similar topologies that those obtained with real rs-fMRI data. This opens new perspectives to predict and better understand the brain functional reorganization occuring in individual MS patients during disease progression or treatment.

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