Abstract #3182

Brain volume asymmetries and 1H-MRS of Posterior Cingulate Cortex in the differential diagnosis of Primary Progressive Aphasia

Micaela Mitolo¹, Michelangelo Stanzani-Maserati², Stefania Evangelisti¹, Lia Talozzi¹, Laura Ludovica Gramegna^1,2, Lorenzo Cirignotta¹, Claudio Bianchini¹, Federico Oppi², Roberto Poda², Roberto Gallassi², Giovanni Rizzo^2,3, Luisa Sambati², Piero Parchi², Sabina Capellari^2,3, Rocco Liguori^2,3, David Neil Manners¹, Claudia Testa⁴, Raffaele Lodi^1,2, and Caterina Tonon^1,2

¹Department of Biomedical and NeuroMotor Sciences, Functional MR Unit, University of Bologna, Bologna, Italy, Bologna, Italy, ²IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, Bologna, Italy, ³Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy, Bologna, Italy, ⁴Department of Physics and Astronomy, University of Bologna, Bologna, Italy, Bologna, Italy

Differential diagnosis of neurodegenerative diseases is a great challenge for both clinic practice and research. We investigated the ability of magnetic resonance spectroscopy (1H-MRS) of Posterior Cingulate Cortex (PCC) and brain volume asymmetries to differentiate patients with Primary Progressive Aphasia (PPA) from patients with Alzheimer’s disease (AD). The N-acetyl-aspartate to myo-inositol ratio (NAA/mI ratio) in the PCC discriminates APP from AD (p = 0.009) with an accuracy of 75.5%. Furthermore, ROC curve analyses of all statistically significant asymmetry indexes were performed and the PCC showed the highest level of accuracy (81.4%) in discriminating between the two neurodegenerative groups.

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