Meeting Banner
Abstract #3187

Hippocampal cerebrovascular reactivity is associated with obesity in women. An arterial spin labeling study.

Lidia Glodzik1,2, Henry Rusinek2, Wai Tsui1, Yi Li1, Pippa Storey2, Ricardo Osorio1, Tracy Butler1, and Mony de Leon1

1Psychiatry, NYU School of Medicine, New York, NY, United States, 2Radiology, NYU School of Medicine, New York, NY, United States

Cerebrovascular reactivity to carbon dioxide (CVR-CO2) is impaired in conditions affecting cerebral vasculature. Obesity increases the risk of Alzheimer’s disease (AD). The hippocampus plays a prominent role in cognition and it is one of the earliest brain structures affected during the progression of AD. It remains uncertain how obesity affects cerebral vasculature in AD vulnerable regions. We examined the relationship between body mass index and neocortical and hippocampal vasoreactivity. Our pulsed ASL sequence combined a flow-sensitive alternating inversion-recovery labeling scheme with balanced steady-state free precession to optimize spatial resolution and lower sensitivity to susceptibility artifacts. Cerebral blood flow (CBF) measurements were done during rest and rebreathing challenge designed to increased CO2 level. In obese women (BMI≥30, n=36) hippocampal vasoreactivity was 80% lower than in their non-obese peers. No relationship was observed in men or with respect to cortical vasoreactivity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here