Abstract #3189

Evaluation of the magnetization exchange in catecholaminergic nuclei at 3 T

Nikos Priovoulos¹, Stan van Boxel¹, Heidi IL Jacobs^1,2,3, Benedikt A Poser², and Dimo Ivanov²

¹Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ²Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States

Magnetization Transfer (MT) weighted gradient echo techniques can be used favourably instead of typical spin-echo based approaches for high-resolution imaging of the Locus Coeruleus (LC), which is of interest in various diseases. Examining the MT properties of the LC is needed for the development of quantitative biomarkers. Employing a fast, high-resolution acquisition sequence we show that it is possible to obtain data to fit a two-pool MT exchange model in the LC. The LC shows differential MT behavior compared to other catecholaminergic and adjacent GM regions consistent with reduced macromolecular content.

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