Meeting Banner
Abstract #3189

Evaluation of the magnetization exchange in catecholaminergic nuclei at 3 T

Nikos Priovoulos1, Stan van Boxel1, Heidi IL Jacobs1,2,3, Benedikt A Poser2, and Dimo Ivanov2

1Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, 2Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 3Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States

Magnetization Transfer (MT) weighted gradient echo techniques can be used favourably instead of typical spin-echo based approaches for high-resolution imaging of the Locus Coeruleus (LC), which is of interest in various diseases. Examining the MT properties of the LC is needed for the development of quantitative biomarkers. Employing a fast, high-resolution acquisition sequence we show that it is possible to obtain data to fit a two-pool MT exchange model in the LC. The LC shows differential MT behavior compared to other catecholaminergic and adjacent GM regions consistent with reduced macromolecular content.

This abstract and the presentation materials are available to members only; a login is required.

Join Here