Abstract #3191

Cerebral mapping of glutamate with GluCEST MRI in a rat model of stress-induced sleep disturbance

Do-Wan Lee¹, Dong-Hoon Lee², Chul-Woong Woo³, Jae-Im Kwon⁴, Yeon-Ji Chae³, Su Jung Ham¹, Ji-Yeon Suh¹, Sang-Tae Kim³, Jeong Kon Kim⁵, Kyung Won Kim⁵, Jin Seong Lee⁵, Choong Gon Choi⁵, and Dong-Cheol Woo^3,6

¹Center for Bioimaging of New Drug Development, and MR Core, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ²Faculty of Health Sciences and Brain & Mind Centre, The University of Sydney, Sydney, Australia, ³MR Core, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁴Department of Nuclear Medicine, Avison Biomedical Research Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁵Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ⁶Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of

GluCEST is a powerful neuroimaging tool, can detect in vivo glutamate signals involving neurotransmitter metabolism in the central nervous system. We measured glutamate signal changes in the hippocampus and cortex of a rat model of stress-induced perturbed sleep, using in vivo GluCEST and high-resolution ¹H-MRS. The CEST signal in control and sleep-perturbed rats revealed significant findings on GluCEST contrast values and metabolic concentrations in both regions. Our in vivo GluCEST and ¹H-MRS results may yield valuable insights in the alterations of cerebral glutamate signals in sleep disorders.

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