Abstract #3193

In Vivo Evidence of Brain Glutamate Level Changes in a Multiple Sclerosis Rat Model Using Glutamate Chemical Exchange Saturation Transfer (GluCEST) Imaging

Dong-Hoon Lee¹, Chul-Woong Woo², Jae-Im kwon³, Yeon-Ji Chae², Su Jung Ham⁴, Ji-Yeon Suh⁴, Sang-Tae Kim², Jeong Kon Kim⁵, Kyung Won Kim⁵, Jin Seong Lee⁵, Choong Gon Choi⁵, Dong-Cheol Woo^2,6, and Do-Wan Lee⁴

¹Faculty of Health Sciences and Brain & Mind Centre, The University of Sydney, Sydney, Australia, ²MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ³Department of Nuclear Medicine, and Avison Biomedical Research Center, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Center for Bioimaging of New Drug Development, and MR Core Laboratory, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁵Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ⁶Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of

GluCEST imaging is a novel molecular MRI imaging technique that provides in vivo image contrast by glutamate concentration changes. In this abstract, we attempted to evaluate signal changes in hippocampus and corpus callosum at a multiple sclerosis rat model based on the quantified GluCEST signals. We also evaluated and compared the signals with those in the control group to demonstrate the glutamate signal differences. Our results clearly showed that GluCEST imaging could be a useful tool to evaluate the brain metabolism in the brain multiple sclerosis, and it provides quantitative results highly related with the in vivo glutamate level changes.

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