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Abstract #3199

In Vivo MRI Reveals Increased  Brain Prefusion in Carbamoylated Erythropoietin Treated Mice

Yutong Liu1, Monica Sathyanesan2,3, and Samuel S Newton2,3

1Radiology, University of Nebraska Medical Center, Omaha, NE, United States, 2Basic Biomedical Sciences, University of South Dakota, Vermillion, SD, United States, 3Sioux Falls VA HealthCare System, Sioux Falls, SD, United States

In vivo MRI was used to detect and measure the brain hemodynamic action of carbamoylated erythropoietin (Cepo) in mice. Brain perfusion was measured using dynamic susceptibility contrast MRI, and BBB permeability was detected by pre- and post-contrast T1 mapping. It was found that Cepo caused increased cerebral blood flow and volume. Consistent pre- and post-contrast T1 values indicated no gadolinium leakage from vascular system to brain tissue. In summary, chronic Cepo treatment induced increased brain perfusion and this can be detected using in vivo MRI.

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