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Abstract #3202

4D Real-time BOLD MRI in Genetically Engineered Mouse Brains with Acute Hypoxia Challenge

Anthony G Christodoulou1, George C Gabriel2, Cecilia W Lo2, and Yijen L Wu2,3

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 3Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States

The objective of this study is to develop 4D time-resolved high-resolution BOLD MRI by combining low-rank sparse imaging and compressed sensing. By expressing a dynamic BOLD image as the product of a set of basis images and temporal functions, we are able to capture differential dynamic BOLD responses to oscillating hypoxia challenge in high-resolution 3D space in genetically engineered mouse brains.

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