Abstract #3202

4D Real-time BOLD MRI in Genetically Engineered Mouse Brains with Acute Hypoxia Challenge

Anthony G Christodoulou¹, George C Gabriel², Cecilia W Lo², and Yijen L Wu^2,3

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, ³Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States

The objective of this study is to develop 4D time-resolved high-resolution BOLD MRI by combining low-rank sparse imaging and compressed sensing. By expressing a dynamic BOLD image as the product of a set of basis images and temporal functions, we are able to capture differential dynamic BOLD responses to oscillating hypoxia challenge in high-resolution 3D space in genetically engineered mouse brains.

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