Abstract #3220

Structural changes in a rat model of traumatic brain injury and challenges of preclinical registration in the presence of lesions

Maria Yanez Lopez¹, Nicoleta Baxan², Cornelius Donat¹, Pete Hellyer³, Mazdak Ghajari⁴, Magdalena Sastre¹, and David Sharp¹

¹Medicine, Imperial College London, London, United Kingdom, ²Biological Imaging Centre, Imperial College London, London, United Kingdom, ³Neuroimaging, King's College London, London, United Kingdom, ⁴Dyson School of Design Engineering, Imperial College London, London, United Kingdom

The aim of this work was to develop an automated pipeline to study structural changes in a rat model of TBI using T1/T2-weighted images. Our results show that the CCI model causes focal alterations in grey matter in the proximity of the injury, with a visible edema 14 days after injury in T2-weighted images, plus damage in the white matter (corpus callosum). These hyper-intense lesions complicate registration and require optimisation of the affine step, together with skull stripping of the brain of injured rats.

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