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Abstract #3228

Evaluation of Diffusion-Weighted Imaging of the Macaque Brains Using Diffusion-Prepared TSE

Jialu Zhang1,2, Dingxin Wang2, Xiufeng Li2, Kamil Ugurbil2, Anna Wang Roe1, and Xiaotong Zhang1

1Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Center for Magnetic Resonance Research, School of Medicine, University of Minnesota, Minneapolis, MN, United States

A major challenge with EPI-based diffusion-weighted imaging (dMRI) is magnetic field inhomogeneity-associated distortion and signal loss. We implemented a mono-polar diffusion-preparation module for TSE sequence (DP-TSE) as an alternative to achieve distortion-free, high-resolution diffusion imaging with improved signal-to-noise ratio (SNR). Such an approach has been demonstrated in human subjects with a promising potential. We want to further evaluate the robustness of the implemented DP-TSE sequence and the feasibility of applying this approach for anesthetized macaques, and investigate whether DP-TSE is superior to alternative dMRI method in terms of imaging quality and SNR efficiency.

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