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Abstract #3230

Voxelwise and morphometric analysis using diffusion tensor MRI microscopy reveals distinct microstructural and morphometric abnormalities in ferret brain development after gestational infection with the Zika virus

Elizabeth B Hutchinson1,2, Laura D Reyes1,2, Okan Irfanoglu1, Sharon L Juliano3, and Carlo Pierpaoli1

1NIBIB, NIH, Bethesda, MD, United States, 2Henry M. Jackson Foundation, Inc, Bethesda, MD, United States, 3APG, USUHS, Bethesda, MD, United States

An efficient pipeline for the processing and analysis of diffusion MRI microscopy data has been applied to study neurodevelopmental abnormaities in a ferret model of Zika infection. Individual and group differences in DTI values were found using Z-score and Cohen’s D maps to compare Zika treated and untreated P0 ferret brain specimens. Morphometric abnormalities were also identified using DTI-driven tensor based morphometry (DTBM) to show reduced local volume in the developing cortex. These results highlight the utility of this pipeline and advance the basic understanding of neurodevelopmental abnormalities that can result from exposure to the Zika virus during gestation.

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