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Abstract #3233

Vulnerable Networks in the Aging Mouse Brain

Wenlin Wu1, Robert J Anderson2, Serge Koudoro3, Eleftherios Garyfallidis 3, David Dunson4, Carol A Colton5, and Alexandra Badea2

1Pratt School of Engineering, Duke University, Durham, NC, United States, 2Radiology, Duke Univ Medical Center, Durham, NC, United States, 3School of Informatics, Computing and Engineering, University of Indiana, Bloomington, IN, United States, 4Statistical Science, Duke University, Durham, NC, United States, 5Duke University Medical Center, Durham, NC, United States

Despite recent advances in aging research, the underlying mechanisms of selective brain vulnerability to aging remain to be elucidated. Mouse models may provide useful tools to dissect the mechanisms behind age and sex associated vulnerability of brain circuits. We used high resolution accelerated protocols and tensor network analyses to reveal structural network differences in aging C57BL/6 mice.

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