Abstract #3233

Vulnerable Networks in the Aging Mouse Brain

Wenlin Wu¹, Robert J Anderson², Serge Koudoro³, Eleftherios Garyfallidis ³, David Dunson⁴, Carol A Colton⁵, and Alexandra Badea²

¹Pratt School of Engineering, Duke University, Durham, NC, United States, ²Radiology, Duke Univ Medical Center, Durham, NC, United States, ³School of Informatics, Computing and Engineering, University of Indiana, Bloomington, IN, United States, ⁴Statistical Science, Duke University, Durham, NC, United States, ⁵Duke University Medical Center, Durham, NC, United States

Despite recent advances in aging research, the underlying mechanisms of selective brain vulnerability to aging remain to be elucidated. Mouse models may provide useful tools to dissect the mechanisms behind age and sex associated vulnerability of brain circuits. We used high resolution accelerated protocols and tensor network analyses to reveal structural network differences in aging C57BL/6 mice.

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