Abstract #3235

Ultra-high-resolution postmortem MRI of cortical lesions in a nonhuman primate model of multiple sclerosis

Maxime Donadieu¹, Diego Szczupak², Seung Kwon Ha¹, Daniel T Abraham¹, Emily C Leibovitch³, Joseph R Guy¹, Cecil CC Yen², Erin S Beck¹, Afonso C Silva², Steve Jacobson³, Pascal Sati¹, and Daniel S Reich¹

¹Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ²Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institutes of Health, Bethesda, MD, United States, ³Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

Experimental autoimmune encephalomyelitis (EAE) in the common marmoset (Callithrix jacchus) shares important pathological and radiological similarities with MS. However, cortical pathology in this model has not been investigated by MRI. The purpose of this study is to examine, for the first time, whether cortical lesions can be visualized by MRI in this model. Similar to MS patients, we report the MRI detection of MS-like cortical lesions in postmortem EAE marmoset. These findings further reinforce the proximity between this animal model and the human disease.

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