Abstract #3240

Clinical reliability of 3D whole-brain vessel wall imaging in patients with intracranial atherosclerotic disease: a comparison with conventional targeted imaging

Na Zhang¹, Xinfeng Liu^1,2, Qi Yang³, Shlee S. Song⁴, Zhenliang Xiong^1,5, Lei Zhang¹, Hairong Zheng¹, Xin Liu¹, and Zhaoyang Fan^3,6

¹Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Radiology, Guizhou Provicial People's Hospital, Guiyang, China, ³Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, ⁴Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, United States, ⁵Guizhou University School Of Medicine, Guiyang, China, ⁶Department of Medicine, University of California, Los Angeles, CA, United States

Conventional intracranial MR vessel wall imaging (VWI) techniques based on 3D turbo spin-echo (TSE), with a thin, oblique slab to specifically target a limited imaging volume, have been shown to be reliable in quantifying vessel morphology of intracranial atherosclerotic disease (ICAD). Recently, 3D whole-brain VWI was proposed and optimized offering large spatial coverage, improved cerebrospinal fluid suppression, and enhanced T1 weighting and exhibits excellent reproducibility in quantification of vessel dimensions in healthy volunteers. This study is to further evaluate the clinical reliability of 3D whole-brain VWI in patients with ICAD via a comparison with 3D targeted VWI and 2D TSE.

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