Abstract #3242

Highly Accelerated Whole Brain Isotropic 0.5mm Intracranial Vessel Wall Imaging with Nonlocal Denoising and Super Resolution Enhancement

Zechen Zhou¹, Baocheng Chu², Jie Sun², Niranjan Balu², Mahmud Mossa-basha², Thomas Hatsukami^2,3, Peter Börnert⁴, and Chun Yuan^2,5

¹Philips Research North America, Cambridge, MA, United States, ²Department of Radiology, University of Washington, Seattle, WA, United States, ³Department of Surgery, Division of Vascular Surgery, University of Washington, Seattle, WA, United States, ⁴Philips Research Hamburg, Hamburg, Germany, ⁵Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China

The three-dimensional (3D) turbo spin echo (TSE) sequence with variable flip angle (VFA) has proven to be clinically useful for high resolution intracranial vessel wall imaging (VWI) at 3T. In this study, a T1 weighted 3D TSE sequence was optimized for whole brain isotropic 0.5mm intracranial VWI in 8mins28secs. The optimized VFA design improves the flow suppression in small vessels and the nonlocal denoising effectively reduces the noise amplification after super resolution enhancement while improving the vessel wall boundary definition. This combined imaging and post-processing technique provides a promising tool for intracranial atherosclerosis and stroke investigation.

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