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Abstract #3260

Vessel-specific Quantification of Neonatal Cerebral Venous Oxygenation

Dengrong Jiang1, Hanzhang Lu2, Charlamaine Parkinson3, Pan Su2, Zhiliang Wei2, Li Pan4, Aylin Tekes2, Thierry A.G.M. Huisman2, W. Christopher Golden3, and Peiying Liu2

1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Siemens Healthineers, Baltimore, MD, United States

Cerebral metabolic rate of oxygen (CMRO2) is an important biomarker for normal and pathological neonatal brain development. However, regional measurement of neonatal CMRO2 has been limited due to an inability to evaluate regional venous blood oxygenation (Yv). This study presented a rapid MRI technique, accelerated T2-relaxation-under-phase-contrast (aTRUPC), to measure vessel-specific Yv in neonates. We have improved the reliability and accuracy of aTRUPC by optimizing imaging parameters and calibrating T2-bias. A pilot study on healthy, non-sedated neonates demonstrated the feasibility of aTRUPC to measure vessel-specific Yv. Accuracy of aTRUPC-based Yv measurements was further validated with established whole-brain Yv measurement using T2-relaxation-under-spin-tagging.

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