Due to limitations in anaesthetic protocol, fMRI studies of recovery following ischaemic stroke in rodents show high variability and must use large numbers of animals. This study uses a novel anaesthetic protocol which gives a highly reproducible BOLD signal in healthy animals to study changes in response to forepaw stimulation in 10 rats following middle cerebral artery occlusion. Even with the improved protocol, high variability between animals following MCAO is a confounding factor, and while a trend towards hyperactivation followed by return to baseline is seen, a larger number of animals is still required for longitudinal studies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords