Meeting Banner
Abstract #3275

Longitudinal functional MRI mapping changes in neurovascular responses following middle cerebral artery occlusion

Andrew Crofts1, Melissa Trotman-Lucas2, Justyna Janus3, Claire Gibson2, and Michael Kelly3

1Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, United Kingdom, 2School of Psychology, University of Nottingham, Nottingham, United Kingdom, 3Core Biotechnology Services, University of Leicester, Leicester, United Kingdom

Due to limitations in anaesthetic protocol, fMRI studies of recovery following ischaemic stroke in rodents show high variability and must use large numbers of animals. This study uses a novel anaesthetic protocol which gives a highly reproducible BOLD signal in healthy animals to study changes in response to forepaw stimulation in 10 rats following middle cerebral artery occlusion. Even with the improved protocol, high variability between animals following MCAO is a confounding factor, and while a trend towards hyperactivation followed by return to baseline is seen, a larger number of animals is still required for longitudinal studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here