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Abstract #3277

Resting State Olfactory Network Functional Connectivity in Tremor- and Rigidity-predominant Patients with Parkinson’s disease

Lu Jiaming1, Rachel Stanford1, Prasanna Karunanayaka1, Qing Yang1, Paul Eslinger2, and Xuemei Huang2

1Radiology, Penn State University, Hershey, PA, United States, 2Neurology, Penn State University, Hershey, PA, United States

Parkinson's disease (PD) is a neurodegenerative disease, consisting of a broad spectrum of motor and non-motor symptoms. We used resting-state fMRI to investigate differences in functional connectivity (FC) of the olfactory network (ON) in two major PD subtypes: akinetic-rigid (PDAR) and tremor predominant (PDT). Significant differences in ON FC were found between normal controls, PDAR, and PDT groups in six brain regions. Lower FC was observed in the orbitofrontal cortex, insula, and posterior cingulate cortex in the PDAR group compared to the PDT group. Our findings suggest that the ON FC is deferentially affected in the two PD subtypes.

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