Abstract #3277

Resting State Olfactory Network Functional Connectivity in Tremor- and Rigidity-predominant Patients with Parkinson’s disease

Lu Jiaming¹, Rachel Stanford¹, Prasanna Karunanayaka¹, Qing Yang¹, Paul Eslinger², and Xuemei Huang²

¹Radiology, Penn State University, Hershey, PA, United States, ²Neurology, Penn State University, Hershey, PA, United States

Parkinson's disease (PD) is a neurodegenerative disease, consisting of a broad spectrum of motor and non-motor symptoms. We used resting-state fMRI to investigate differences in functional connectivity (FC) of the olfactory network (ON) in two major PD subtypes: akinetic-rigid (PD_AR) and tremor predominant (PD_T). Significant differences in ON FC were found between normal controls, PD_AR, and PD_T groups in six brain regions. Lower FC was observed in the orbitofrontal cortex, insula, and posterior cingulate cortex in the PD_AR group compared to the PDT group. Our findings suggest that the ON FC is deferentially affected in the two PD subtypes.

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