Abstract #3291

Application of multi-shell NODDI to characterize acute and chronic MS lesions.

Simone Sacco^1,2, Eduardo Caverzasi^2,3, Tristan Gundel², Shuiting Cheng ², Carlo Asteggiano^1,2, Christian Cordano², Antjie Bischof², Gina Kirkish², Gillian Rush², Nico Papinutto², Stefano Bastianello³, Bruce A.C. Cree², Stephen L. Hauser², and Roland G. Henry²

¹Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy, ²Department of Neurology, University of California San Francisco, San Francisco, CA, United States, ³Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

In order to overcome the limitations of conventional MRI in MS, we explored the ability of NODDI to characterize features of acute and chronic lesions. In our study, in line with a recent work that histologically investigated animal models, Orientation Dispersion Index (ODI) was significantly higher in enhancing lesions, thus representing a reliable tool for detecting acute inflammation. After enhancement, lesions could be divided based on their change in Neurite Density Index (NDI): lesions showing increasing NDI values were likely to be characterized by partial remyelination, whereas lesions showing decreasing NDI values might be expression of chronic focal damage.

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