Abstract #3313

Myelin imaging derived from quantitative parameter mapping

Yuki Kanazawa¹, Masafumi Harada¹, Yo Taniguchi², Hiroaki Hayashi³, Takashi Abe¹, Maki Otomo¹, Yuki Matsumoto¹, Masaharu Ono⁴, Yoshitaka Bito⁴, and Akihiro Haga¹

¹Tokushima University, Tokushima, Japan, ²Research & Development Group, Hitachi, Ltd., Tokyo, Japan, ³Kanazawa University, Kanazawa, Japan, ⁴Healthcare Business Unit, Hitachi, Ltd., Tokyo, Japan

We developed a novel method which is applicable to visualize myelin component in the human brain using relaxation time derived from QPM-MRI. Our method demonstrated acknowledgement that the myelin content increased proportionally by times R₁ and R₂ in healthy volunteers. Linear regression analysis showed a strong and highly significant correlation between conventional T₁w/T₂w ratios and R₁·R₂^* times derived from QPM (R = 0.61, P < 0.0001). In conclusion, our myelin mapping technique using QPM may replace conventional T₁w/T₂w ratio mapping and be expected to become independent of measurement conditions due to having quantitative characteristic of QPM itself.

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