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Abstract #3313

Myelin imaging derived from quantitative parameter mapping

Yuki Kanazawa1, Masafumi Harada1, Yo Taniguchi2, Hiroaki Hayashi3, Takashi Abe1, Maki Otomo1, Yuki Matsumoto1, Masaharu Ono4, Yoshitaka Bito4, and Akihiro Haga1

1Tokushima University, Tokushima, Japan, 2Research & Development Group, Hitachi, Ltd., Tokyo, Japan, 3Kanazawa University, Kanazawa, Japan, 4Healthcare Business Unit, Hitachi, Ltd., Tokyo, Japan

We developed a novel method which is applicable to visualize myelin component in the human brain using relaxation time derived from QPM-MRI. Our method demonstrated acknowledgement that the myelin content increased proportionally by times R1 and R2 in healthy volunteers. Linear regression analysis showed a strong and highly significant correlation between conventional T1w/T2w ratios and R1ยทR2* times derived from QPM (R = 0.61, P < 0.0001). In conclusion, our myelin mapping technique using QPM may replace conventional T1w/T2w ratio mapping and be expected to become independent of measurement conditions due to having quantitative characteristic of QPM itself.

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