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Abstract #3315

Amide proton transfer in amyotrophic lateral sclerosis

Zhuozhi Dai1,2, Sanjay Kalra1, Dennell Mah1, Peter Seres1, Gen Yan3, Hongfu Sun4, Zhiwei Shen5, Renhua Wu5, and Alan H. Wilman1

1University of Alberta, Edmonton, AB, Canada, 2Radiology, 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China, 3Affiliated Hospital of Jiangnan University, Wuxi, China, 4Hotchkiss Brain Institute, Calgary, AB, Canada, 52nd Affiliated Hospital of Shantou University Medical College, Shantou, China

There is lack of objective imaging indicators for ALS diagnosis and assessment. Our hypothesis is that amide is altered due to neurodegeneration in ALS, and this alteration will be visible on APT images. This study aims to explore the value of APT in ALS patients as a possible image biomarker of disease. Thirty-two participants were recruited as part of the Canadian ALS Neuroimaging Consortium. This study first demonstrated changes of APT in the motor cortex and corticospinal tract of ALS patients. The combination of APT and DTI can simultaneously detect changes of metabolism and microstructure in ALS patients.

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