Abstract #3315

Amide proton transfer in amyotrophic lateral sclerosis

Zhuozhi Dai^1,2, Sanjay Kalra¹, Dennell Mah¹, Peter Seres¹, Gen Yan³, Hongfu Sun⁴, Zhiwei Shen⁵, Renhua Wu⁵, and Alan H. Wilman¹

¹University of Alberta, Edmonton, AB, Canada, ²Radiology, 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China, ³Affiliated Hospital of Jiangnan University, Wuxi, China, ⁴Hotchkiss Brain Institute, Calgary, AB, Canada, ⁵2nd Affiliated Hospital of Shantou University Medical College, Shantou, China

There is lack of objective imaging indicators for ALS diagnosis and assessment. Our hypothesis is that amide is altered due to neurodegeneration in ALS, and this alteration will be visible on APT images. This study aims to explore the value of APT in ALS patients as a possible image biomarker of disease. Thirty-two participants were recruited as part of the Canadian ALS Neuroimaging Consortium. This study first demonstrated changes of APT in the motor cortex and corticospinal tract of ALS patients. The combination of APT and DTI can simultaneously detect changes of metabolism and microstructure in ALS patients.

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