In this study, coarse-to-fine evaluations were creatively made in terms of both global volume and local shape to identify Wilson’s disease (WD)-related morphometric abnormalities of eight structures of interest (caudate, putamen, globus pallidus, thalamus, amygdala, hippocampus, red nucleus and substantia nigra). Our results revealed that significant volume reductions and region-specific surface atrophy were detected in all structures of interest except the bilateral hippocampus in patients with WD relative to HC subjects, and the putamen had the strongest global and local atrophy and the amygdala was least affected. These morphometric abnormalities may serve as useful imaging biomarkers for WD.
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