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Abstract #3352

Whole-brain DTI at 860 μm isotropic resolution in 10 minutes on a commercial 3T Scanner

Yunsong Liu1, Congyu Liao2, Kawin Setsompop2, and Justin P. Haldar1

1Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States, 2Martinos Center for Biomedical Imaging, Charlestown, MA, United States

We describe an acquisition and reconstruction methodology that enables in vivo human diffusion tensor imaging with whole-brain coverage and 860$$$\mu$$$m isotropic spatial resolution, all within a 10 minute acquisition window on a commercial 3T scanner. Our approach is enabled by combining the gSlider-SMS acquisition approach (which uses simultaneous multi-slab acquisition for increased spatial coverage, combined with highly-efficient RF slab-encoding to achieve high spatial resolution) with an SNR-enhancing joint reconstruction approach that mitigates the noise associated with high-resolution acquisition.

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