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Abstract #3365

White matter parcellation test-retest reproducibility of diffusion MRI tractography fiber clustering

Fan Zhang1, Ye Wu1, Isaiah Norton1, Yogesh Rathi1, Alexandra J. Golby1, and Lauren J. O'Donnell1

1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Fiber clustering is a popular strategy for automated white matter parcellation using diffusion MRI tractography. However, there has been no investigation to assess fiber clustering parcellation test-retest reproducibility, i.e. whether white matter parcellations could be reliably reproduced in repeated scans. This work presents the first study of fiber clustering white matter parcellation test-retest reproducibility. We perform evaluation on a large test-retest dataset, including a total of 255 subjects from multiple independently acquired datasets. Our results in general indicate that the fiber clustering method produced more reproducible white matter parcellations than a popular cortical-parcellation-based method.

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