Fiber clustering is a popular strategy for automated white matter parcellation using diffusion MRI tractography. However, there has been no investigation to assess fiber clustering parcellation test-retest reproducibility, i.e. whether white matter parcellations could be reliably reproduced in repeated scans. This work presents the first study of fiber clustering white matter parcellation test-retest reproducibility. We perform evaluation on a large test-retest dataset, including a total of 255 subjects from multiple independently acquired datasets. Our results in general indicate that the fiber clustering method produced more reproducible white matter parcellations than a popular cortical-parcellation-based method.
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