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Abstract #3367

A novel connectomics metric for investigating the structural-functional relationship in the brain

Oren Civier1,2, Marion Sourty1,2, and Fernando Calamante1,2,3,4

1School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, Australia, 2Brain and Mind Centre, The University of Sydney, Sydney, Australia, 3Sydney Imaging, The University of Sydney, Sydney, Australia, 4Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

We present a novel connectomics metric that quantifies the relationship between structural connectivity (SC) and functional connectivity (FC) in each connection in the brain. The metric is based on a biologically meaningful and quantitative measure of SC, followed by normalization of both modalities to a common scale. We demonstrated the utility of the metric in examining structural-functional relationships in pairs of homologous connections, detecting homologues that are dissimilar. The metric is more informative than using FC in isolation, and might provide insights into factors that contribute to FC beyond the strength of SC (e.g., indirect connections, organization of fibres).

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