We present a novel connectomics metric that quantifies the relationship between structural connectivity (SC) and functional connectivity (FC) in each connection in the brain. The metric is based on a biologically meaningful and quantitative measure of SC, followed by normalization of both modalities to a common scale. We demonstrated the utility of the metric in examining structural-functional relationships in pairs of homologous connections, detecting homologues that are dissimilar. The metric is more informative than using FC in isolation, and might provide insights into factors that contribute to FC beyond the strength of SC (e.g., indirect connections, organization of fibres).
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