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Abstract #3388

Characterization of the cerebro-cerebellar loop exploiting advanced tractography and dealing with thalamic synapsis

Fulvia Palesi1, Nicolò Rolandi2, Fernando Calamante3,4, Egidio D'Angelo2,5, and Claudia A.M. Gandini Wheeler-Kingshott2,6,7

1Neuroradiology Unit, Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Italy, 2Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 3School of Aerospace Mechanical and Mechatronic Engineering, University of Sydney, Sydney, Australia, 4Sydney Imaging, University of Sydney, Sydney, Australia, 5Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy, 6Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 7Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Italy

Recently, advanced tractography has been used for assessing the feasibility of characterizing cerebro-cerebellar loop, composed of cerebello-thalamo-cortical and cortico-ponto-cerebellar pathways, acknowledging the issue of how tractography deals with polysynaptic connectivity, i.e. at thalamic level. In this work, polysynaptic cerebello-thalamo-cortical and cortico-ponto-cerebellar pathways were reconstructed using a multiplicative hypothesis for thalamic connectivity. Our findings revealed the importance of using such a multiplication factor for streamlines reaching the thalamic synapses to properly reconstruct cerebro-cerebellar connection. Furthermore, findings using polysynaptic tracts support the cerebellar role in cognition showing that cognitive/associative areas are the mainly involved in both the cerebello-thalamo-cortical and cortico-ponto-cerebellar pathways.

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