Diffusion-Weighted imaging is a mainstay for oncologic examinations. However, abdominal examinations with standard DWI can be challenged by signal exploration and motion artifacts. This prospective study therefore compares a standard EPI-DWI with an oncologically optimized-DWI, including complex averaging, motion correction between averages, rescaling of motion corrupted averages, and background suppression, in oncological follow-up MRI investigations. A diffusion resolution phantom demonstrated an improved image quality by the optimized-DWI. Image quality analysis of prospectively acquired abdominal DWI MRI examinations in 52 patients showed a significant improvement in image quality and apparent signal-to-background-noise-ratio by optimized-DWI as compared to standard EPI-DWI in oncologic imaging.