Abstract #3405

Correction of motion artifacts in head and neck diffusion-weighted MRI

Nienke D. Sijtsema^1,2, Dirk H.J. Poot^2,3, Gerda M. Verduijn¹, Mischa S. Hoogeman¹, Aad van der Lugt², Steven F. Petit¹, and Juan A. Hernandez-Tamames²

¹Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, Netherlands, ²Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, ³Department of Medical Informatics, Erasmus MC, Rotterdam, Netherlands

Diffusion-weighted imaging (DWI) is a promising technique for early stratification of responders and non-responders in head and neck chemoradiotherapy. However, data corruption due to swallowing and misalignment reduce the precision of estimated DWI parameters. We investigated different post-processing approaches to improve the reproducibility of the apparent diffusion coefficient (ADC) and demonstrated an improvement in reproducibility from 13.2% to 6.7%. Inter-volume registration showed the largest improvement compared to intra-volume registration and swallowing artifact rejection. The 6.7% reproducibility is sufficient for stratification of responders and non-responders in H&N chemoradiotherapy.

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