Multi-shot diffusion-weighted echo-planar imaging (DW-EPI) with multiplexed sensitivity encoding (MUSE) is a self-navigated technique that can achieve high resolution diffusion-tensor imaging (DTI) without the need of navigator echo. However, even with multi-shot acquisition, the effective echo spacing is still relatively long for acquisition of high resolution DTI, leading to significant geometric distortion. In this study, we aim to reduce the geometric distortion of multi-shot DW-EPI by 1) integrating the reversed gradient acquisition in multi-shot DW-EPI, and 2) developing a joint reconstruction method that can reconstruct non-uniform k-space data by taking the off-resonance effect into account.
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