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Abstract #3412

Distortion Correction of Multi-Shot Diffusion-Weighted Echo-Planar Imaging using Reversed Gradient Acquisition and Joint Reconstruction

Xiaoxi Liu1, Di Cui1, Edward S. Hui1,2, Queenie Chan3, and Hing-Chiu Chang1

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, 2The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China, 3Philips Healthcare, Hong Kong, China

Multi-shot diffusion-weighted echo-planar imaging (DW-EPI) with multiplexed sensitivity encoding (MUSE) is a self-navigated technique that can achieve high resolution diffusion-tensor imaging (DTI) without the need of navigator echo. However, even with multi-shot acquisition, the effective echo spacing is still relatively long for acquisition of high resolution DTI, leading to significant geometric distortion. In this study, we aim to reduce the geometric distortion of multi-shot DW-EPI by 1) integrating the reversed gradient acquisition in multi-shot DW-EPI, and 2) developing a joint reconstruction method that can reconstruct non-uniform k-space data by taking the off-resonance effect into account.

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