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Abstract #3423

White matter Fractional Anisotropy measures in Autism Spectrum Disorder. Implications of differences in structural correlation with performance IQ measures and age. Results from EU- Autism Interventions data.

Robert Anthony Dallyn1,2, Pedro Angel Luque Laguna1,2,3, Cate Davidson1,2,3, EU-AIMS2 TRIALS Consortium1,2, Declan Murphy1, and Flavio Dell'Acqua1,2

1Forensic and Developmental Neuroscience, King's College London, London, United Kingdom, 2Natbrainlab, King's College London, London, United Kingdom, 3Neuroimaging, King's College London, London, United Kingdom

We present voxel-wise statistics on Fractional Anisotropy from EU-AIMS diffusion imaging data on Autism Spectrum Disorder. We validate previous findings of structural white matter abnormalities in a younger cohort. Correlation analysis of white matter development with behavioural tasks points to altered functioning in ASD individuals in visuospatial reasoning tasks, consistent with the central coherence theory of autism. Cohort differences between ASD and control of white matter integrity correlation with age hint toward altered developmental trajectory in Autism Spectrum individuals.

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