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Abstract #3429

A fixel-based analysis of diffusion properties of white matter fiber in Williams Syndrome

Michael A Green1,2, Kelsie Boulton3, Richard Webster4, Melanie Porter3, and Caroline D Rae1,2

1Neuroscience Research Australia, Sydney, Australia, 2School of Medical Sciences, University of New South Wales, Sydney, Australia, 3Centre for Research in Atypical Neurodevelopment, Macquarie University, Sydney, Australia, 4T.Y. Nelson Department of Neurology, Children's Hospital at Westmead, Sydney, Australia

Williams Syndrome (WS) is a genetic neurodevelopmental disorder produced by a hemideletion of around 26 genes on chromosome 7 (7q11.23) that leads to unique changes in physical and cognitive profiles. Behavioural characteristics including hyper-sociability, excessive friendliness and empathy, sensitivity to loud noises and visual-spatial construction deficits infer unique brain structure and connections. WS is also characterised by reduced muscle tone and a decrease in motor coordination and balance1. We show significant differences in the corticospinal tract in WS participants and that white matter changes previously reported are more likely to be due to morphological changes to the fiber bundles rather than microstructural ones.

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