Williams Syndrome (WS) is a genetic neurodevelopmental disorder produced by a hemideletion of around 26 genes on chromosome 7 (7q11.23) that leads to unique changes in physical and cognitive profiles. Behavioural characteristics including hyper-sociability, excessive friendliness and empathy, sensitivity to loud noises and visual-spatial construction deficits infer unique brain structure and connections. WS is also characterised by reduced muscle tone and a decrease in motor coordination and balance1. We show significant differences in the corticospinal tract in WS participants and that white matter changes previously reported are more likely to be due to morphological changes to the fiber bundles rather than microstructural ones.
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