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Abstract #3443

Application of Whole-Body Diffusion-Weighted MRI Imaging with Apparent Diffusion Coefficient Mapping for the Evaluation of Depth of Response to Therapy in Multiple Myeloma

Menglong Zheng1, Xinxing Ma1, and Daohai Xie1

1The First Affiliated Hospital of Soochow University, Soochow, China

Whole-body diffusion-weighted magnetic resonance imaging (WB-DWI MRI) is an important imaging technique of great supplementary diagnostic value to the evaluation of treatment response in patients with multiple myeloma (MM). Conventional radiography which has been widely avaiable for the identification of myeloma-related bone lesions both at diagnosis and during disease course is of limited value to the assessment of response to therapy or disease relapse in MM, as lytic bone lesions rarely show signs of healing despite response to therapy. WB-DWI MRI with the measurement of apparent diffusion coefficient (ADC) value is an effective way for quantitatively comparing the differences in water diffusion among normal marrow, active pathologic marrow and that in remission. In this work, we report the preliminary results of the application of WB-DWI MRI in discriminating deep response to induction therapy for newly diagnosed MM patients.

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