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Abstract #3455

Quantifying diffusion-weighted MRI parameters with cellular infiltration, tissue ingrowth, and angiogenesis to characterize collagen-sponge remodeling.

Mohammed Salman Shazeeb1,2, Karl Helmer1, Isa Ahmed2, Sivakumar Kandasamy2, Staurt Howes2, Christopher Sotak2, and George Pins2

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Worcester Polytechnic Institute, Worcester, MA, United States

In vivo evaluation of biomaterial implant remodeling involves surgical removal of the implant for subsequent histological assessment, which is often destructive and limits the effective evaluation of these materials. Diffusion-weighted MRI has the potential to non-invasively monitor the remodeling of collagen scaffolds. This study investigated the role of apparent diffusion coefficient (ADC) from different diffusion regimes to evaluate the remodeling of implanted collagen scaffolds and correlated the findings to conventional histological techniques. Correlations between ADC and histological parameters demonstrated that MRI is sensitive to specific remodeling parameters which can aid in the design of robust biomaterial scaffolds for tissue regeneration.

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