In vivo evaluation of biomaterial implant remodeling involves surgical removal of the implant for subsequent histological assessment, which is often destructive and limits the effective evaluation of these materials. Diffusion-weighted MRI has the potential to non-invasively monitor the remodeling of collagen scaffolds. This study investigated the role of apparent diffusion coefficient (ADC) from different diffusion regimes to evaluate the remodeling of implanted collagen scaffolds and correlated the findings to conventional histological techniques. Correlations between ADC and histological parameters demonstrated that MRI is sensitive to specific remodeling parameters which can aid in the design of robust biomaterial scaffolds for tissue regeneration.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords