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Abstract #3479

Diffusion Weighted Imaging with Apparent Diffusion Coefficient on the Assessment of Tumor Heterogeneity for the Differentiation of Molecular Subtypes in Breast Cancer

Joao Vicente Horvat1, Olivia Sutton1, Blanca Bernard-Davila1, Elizabeth Morris1, Katja Pinker1, and Sunitha Thakur1

1Memorial Sloan Kettering Cancer Center, new york, NY, United States

The study evaluated the utility of diffusion weighted imaging with apparent diffusion coefficient on the assessment of tumor heterogeneity for the differentiation of molecular subtypes in a population of 91 patients with invasive breast cancer. The authors investigated the use of histogram analysis and visual assessment of tumor heterogeneity for the differentiation of breast cancer subtypes derived via immunohistochemistry surrogates. The results obtained demonstrated that HER-2 enriched tumors had higher ADC values than other tumor subtypes. It was also demonstrated that histogram analysis and visual assessment of tumor heterogeneity could not reliably be used to differentiate tumor molecular subtypes.

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