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Abstract #3489

Silent Distortionless DWI

Jianmin Yuan1, Yuxin Hu1,2, Anne Menini3, Christopher M. Sandino2, Jesse Sandberg4, Marcus Alley1, Michael Lustig5, Brian Hargreaves1, and Shreyas Vasanawala1

1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, Stanford, CA, United States, 3GE Healthcare, Menlo Park, CA, United States, 4Pediatric Radiology, Lucile Packard Children’s Hospital, Stanford University, Stanford, CA, United States, 5Electrical Engineering and Computer Science, UC Berkeley, Berkeley, CA, United States

Standard clinical EPI based diffusion sequence has high acoustic noise, which is uncomfortable for patients. The images acquired by single-shot EPI also suffer from distortion in areas of large susceptibility variations. To overcome these two limitations, we have developed a silent and distortion-free DWI sequence using a driven equilibrium diffusion prepared multi-segmented Rotating Ultra-Fast Imaging Sequence (RUFIS) readout. The sequence was validated in phantom, volunteers, and patients. The results showed the proposed sequence provides similar diffusion contrast and ADC measurement compared to DW-EPI, with improved image quality and a sound level that approaches that of ambient noise.

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