Standard clinical EPI based diffusion sequence has high acoustic noise, which is uncomfortable for patients. The images acquired by single-shot EPI also suffer from distortion in areas of large susceptibility variations. To overcome these two limitations, we have developed a silent and distortion-free DWI sequence using a driven equilibrium diffusion prepared multi-segmented Rotating Ultra-Fast Imaging Sequence (RUFIS) readout. The sequence was validated in phantom, volunteers, and patients. The results showed the proposed sequence provides similar diffusion contrast and ADC measurement compared to DW-EPI, with improved image quality and a sound level that approaches that of ambient noise.
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