Abstract #3515

Maximising Repeatability: It’s Time to Reconsider the Sampling Scheme for IVIM

Callie Deng¹, Pål Erik Goa², Matthew R. Orton³, Torill E. Sjøbakk¹, Tone F. Bathen¹, and Neil Peter Jerome^1,4

¹Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, ²Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway, ³Division of Radiotherapy & Imaging, Cancer Research UK Cancer Imaging Centre, London, United Kingdom, ⁴Clinic of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, Norway

Diffusion-weighted imaging (DWI) has the potential to improve characterisation and detection of breast cancer. A variety of models are available to fit the relationship between MRI signal and b-value, but the repeatability of such models is often overlooked. In this study, we simulate repeated DWI scans and quantify the precision of IVIM parameters from segmented fitting for D and f; our findings suggest that repeatability of f is highly dependent on disproportionate noise at b=0, and repeatability for f and D can be maximised by redistribution of signal averages. Optimal acquisition strategies for varying values of inter-scan noise are reported.

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