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Abstract #3515

Maximising Repeatability: It’s Time to Reconsider the Sampling Scheme for IVIM

Callie Deng1, Pål Erik Goa2, Matthew R. Orton3, Torill E. Sjøbakk1, Tone F. Bathen1, and Neil Peter Jerome1,4

1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, 2Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway, 3Division of Radiotherapy & Imaging, Cancer Research UK Cancer Imaging Centre, London, United Kingdom, 4Clinic of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, Norway

Diffusion-weighted imaging (DWI) has the potential to improve characterisation and detection of breast cancer. A variety of models are available to fit the relationship between MRI signal and b-value, but the repeatability of such models is often overlooked. In this study, we simulate repeated DWI scans and quantify the precision of IVIM parameters from segmented fitting for D and f; our findings suggest that repeatability of f is highly dependent on disproportionate noise at b=0, and repeatability for f and D can be maximised by redistribution of signal averages. Optimal acquisition strategies for varying values of inter-scan noise are reported.

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