Abstract #3524

Investigating microscopic diffusion anisotropy in the human kidney using multidimensional diffusion encoding

Fabio Nery¹, Filip Szczepankiewicz^2,3, João P. de Almeida Martins^4,5, Matt G Hall¹, Isky Gordon¹, David L Thomas^6,7, and Chris A Clark¹

¹Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom, ²Radiology, Brigham and Women’s Hospital, Boston, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Physical Chemistry, Lund University, Lund, Sweden, ⁵Random Walk Imaging AB, Lund, Sweden, ⁶Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, Queen Square, London, United Kingdom, ⁷Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, United Kingdom

Diffusion tensor imaging (DTI) has been widely used to provide tissue microstructure measures such as fractional anisotropy (FA). Advances in diffusion acquisition methods (e.g. efficient spherical tensor encoding) have enabled more specific microstructural parameters to be derived, including microscopic fractional anisotropy (µFA). This work focused on extending our initial observation of µFA in the kidney through a detailed analysis of the linear and spherical diffusion encoding in healthy subjects, by comparing conventional FA to the µFA in human kidneys, and investigating the technical limitations of the current approach.

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