Abstract #3532

Novel HARDI-ZOOMit protocol detects changes in spinal cord microstructure in patients with asymptomatic non-myelopathic degenerative cervical spinal cord compression

René Labounek^1,2,3, Jan Valošek^1,4, Tomáš Horák^5,6, Alena Svátková^5,7, Petr Bednařík^5,8, Pavel Hok^1,2, Petr Kudlička⁵, Magda Horáková^5,6, Jan Kočica^5,6, Christophe Lenglet⁹, Julien Cohen-Adad¹⁰, Igor Nestrašil^3,9, Josef Bednařík^5,6, and Petr Hluštík^1,2

¹Department of Neurology, Palacký University, Olomouc, Czech Republic, ²Department of Neurology, University Hospital Olomouc, Olomouc, Czech Republic, ³Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, ⁴Department of Biomedical Engineering, University Hospital Olomouc, Olomouc, Czech Republic, ⁵Central European Institute of Technology, Masaryk University, Brno, Czech Republic, ⁶Department of Neurology, University Hospital Brno, Brno, Czech Republic, ⁷Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, ⁸High Field MR Centre, Medical University of Vienna, Vienna, Austria, ⁹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ¹⁰Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada

Detection of degenerative cervical spinal cord compression (DCSCC) at early stage that causes spinal cord (SC) microstructure disruption is limited when current imaging techniques are used. Early detection of damage to SC can predict symptomatic degenerative cervical myelopathy (DCM). We are presenting novel HARDI-ZOOMit protocol (High Angular Resolution Diffusion Imaging + syngo ZOOMit sequence), which is able to detect changes in microstructural diffusion MRI (dMRI) parameters (e.g. fractional anisotropy – FA, mean diffusivity – MD) in asymptomatic DCSCC. Results obtained with HARDI-ZOOMit protocol reveal higher sensitivity when compared to clinical RESOLVE (REadout Segmentation Of Long Variable Echo trains) protocol.

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