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Abstract #3538

An observational study on the diffusion time and field strength dependency of the diffusion coefficient in human white matter

Sebastian Endt1,2, Jan Martin1, Lipeng Ning2, Lars Müller3,4, Andreas Wetscherek3,5, Michael Uder1, Bernhard Hensel6, Yogesh Rathi2, and Frederik B Laun1

1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 3Department Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 5Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, 6Center for Medical Physics and Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Signal dependence on diffusion time has been reported in various tissues and has been connected to cellular restrictions. It is conceivable, however, that it partly originates from relaxation weightings of different compartments. In this study, we investigate the diffusion time dependence of the diffusion tensor in brain tissue at 1.5 T, 3 T and 7 T using a stimulated echo sequence. The results show clear time dependencies of axial and radial diffusivity. 7 T data show a reduction of both diffusivities, indicating a non-negligible role of compartmental relaxation weighting effects.

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