Abstract #3538

An observational study on the diffusion time and field strength dependency of the diffusion coefficient in human white matter

Sebastian Endt^1,2, Jan Martin¹, Lipeng Ning², Lars Müller^3,4, Andreas Wetscherek^3,5, Michael Uder¹, Bernhard Hensel⁶, Yogesh Rathi², and Frederik B Laun¹

¹Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ³Department Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁵Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, ⁶Center for Medical Physics and Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Signal dependence on diffusion time has been reported in various tissues and has been connected to cellular restrictions. It is conceivable, however, that it partly originates from relaxation weightings of different compartments. In this study, we investigate the diffusion time dependence of the diffusion tensor in brain tissue at 1.5 T, 3 T and 7 T using a stimulated echo sequence. The results show clear time dependencies of axial and radial diffusivity. 7 T data show a reduction of both diffusivities, indicating a non-negligible role of compartmental relaxation weighting effects.

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