Advanced diffusion-weighted MRI allows the characterization of cancer tumours noninvasively by estimating cell radius R and volume fraction vin. Existing methods map the apparent R and vin , under the assumption that a given voxel contains one cell population. This work investigates the feasibility of estimating the radii and volume fractions of 2 cell populations co-existing in the same voxel. This method could be useful in studying biphasic tumours like round cell/myxoid liposarcoma, which consist of high-grade and low-grade tumour cells, where the percentage of high-grade cells is strongly related to the risk of metastasis and changes the course of treatment.
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