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Abstract #3540

A Diffusion MRI Approach to Tumour Microstructure Modeling with Two Cell Populations of Different Sizes

Shu Xing1 and Ives R. Levesque1,2

1Medical Physics Unit and Department of Physics, McGill University, Montreal, QC, Canada, 2Research Institute of McGill University Health Center, Montreal, QC, Canada

Advanced diffusion-weighted MRI allows the characterization of cancer tumours noninvasively by estimating cell radius R and volume fraction vin. Existing methods map the apparent R and vin , under the assumption that a given voxel contains one cell population. This work investigates the feasibility of estimating the radii and volume fractions of 2 cell populations co-existing in the same voxel. This method could be useful in studying biphasic tumours like round cell/myxoid liposarcoma, which consist of high-grade and low-grade tumour cells, where the percentage of high-grade cells is strongly related to the risk of metastasis and changes the course of treatment.

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