The widely adopted Standard Model (SM) for diffusion in white matter tissue has been shown to possess intrinsic degeneracies, making parameter estimation from single diffusion encoding (SDE) data ill-conditioned. We extend the SM to a multidimensional diffusion MRI acquisition and analyse the case where the fibre orientation distribution function (fODF) is a Watson distribution. The information contained in the kurtosis tensor, accessed by SDE, is insufficient to recover biophysical model parameters from the MR signal. We prove that Double Diffusion Encoding (DDE), letting us additionally access the full diffusion tensor covariance, makes parameter estimation well-posed.
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