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Abstract #3545

Surface-to-Volume ratio mapping using Oscillating Gradient Diffusion (OGSE) Spectroscopy for cancer characterization in the ex-vivo prostate

Jeevan Shah1, Roger Bourne2, Geoffrey Watson3, and Andre Bongers1

1The University of New South Wales, Sydney, Australia, 2The University of Sydney, Sydney, Australia, 3Royal Prince Alfred Hospital, Sydney, Australia

This study investigates mapping of Surface-to-Volume (S/V) ratios from short diffusion time derived ADC maps to detect and characterize prostate cancer. ADC was mapped using a cos-OGSE DWI (fosc=50-200Hz) in one unfixed prostate (Gleason 4+4). Using a previously established model, S/V and free cytosol diffusivity (D0) maps were estimated by fitting the temporal behaviour of ADC. S/V and D0 were able to clearly and significantly separate the cancer and normal peripheral zone as indicated by a t-test and ROC curves. The geometrical nature of S/V may provide additional information to better characterize prostate cancer independent from diffusion related parameters.

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