Abstract #3547

Random walk simulation of diffusion MRI in geometries constructed from two-photon microscopy of cortical gray matter

Nima Gilani¹, Sven Hildebrand¹, Anna Schueth¹, and Alard Roebroeck¹

¹Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands

The purpose of this study was to more quantitatively characterize the cytoarchitecture of cortical tissue from microscopy in order to simulate diffusion signal in the cortex and to better understand its changes with density, size and permeability of cell bodies, axons and dendrites. Two random walk simulation methods are presented which show effects of cortical laminar microstructure on ADC and K. This could open possibilities of detecting cortical cytoarchitecture, i.e. cell body sizes and densities, and their pathologies with diffusion MRI.

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