Abstract #3579

Resolving crossing fibers with the inclusion of intra-axonal diffusion modeling

Chunyu Song¹, Peng Sun², Zezhong Ye³, and Sheng-Kwei (Victor) Song⁴

¹Biomedical Engineering, Washington University in St. Louis, st louis, MO, United States, ²Radiology, Washington University School of Medicine, St. Louis, MO, United States, University City, MO, United States, ³Chemistry, Washington University in St. Louis, st louis, MO, United States, ⁴Radiology, Washington University School of Medicine, St. Louis, MO, United States, Saint Louis, MO, United States

A new diffusion histology imaging (DHI) model is proposed to model crossing fibers considering both intra- and extra-axonal water diffusion, along with extra-axonal isotropic diffusion within an image voxel. Both Monte-Carlo simulation and in vivo MRI data from one healthy volunteer brain were examined to assess whether DHI can resolve crossing fibers while quantifying axonal injury, demyelination, and inflammation.

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