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Abstract #3591

Apparent Diffusion Coefficient Using Diffusion Weighted MRI and Biochemical Correlates in  Human Breast Cancer

Kavya Umachandran1, Andres Saucedo1, Stephanie Lee-Felker1, Melissa M Joines1, Manoj Kumar Sarma1, Sumit Kumar1, Maggie DiNome2, Nanette DeBruhl1, and Michael Albert Thomas1

1Radiological Sciences, UCLA Geffen School of Medicine, Los Angeles, CA, United States, 2Surgery, UCLA Geffen School of Medicine, Los Angeles, CA, United States

Multiparametric MRI has been investigated in breast and prostate cancer, and other tumors. We evaluated diffusion weighted imaging in a pilot cohort of 20 malignant and 11 benign breast cancer patients, and 7 healthy women. MR spectra were recorded using an accelerated version of five dimensional echo-planar correlated spectroscopic imaging (5D EP-COSI). Significant decline in ADC values of malignant breast cancer compared to benign and healthy women. There was a negative correlation of choline with ADC values in malignant cancer patients. Our findings suggest that choline and lipids can be reliable biomarkers in addition to widely used ADC.

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