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Abstract #3597

A Novel Characterization of Traumatic Brain Injury in White Matter with Diffusion MRI Spherical-Harmonics Rotation Invariants

Mauro Zucchelli1, Drew Parker2, Samuel Deslauriers-Gauthier1, Junghoon John Kim3, Ragini Verma2, and Rachid Deriche1

1Athena Project-Team, INRIA, Sophia Antipolis - Méditerranée, France, 2University of Pennsylvania, Philadelphia, PA, United States, 3Department of Molecular, Cellular, and Biomedical Sciences, CUNY School of Medicine, New York, NY, United States

The current DTI-based markers of traumatic brain injury are able to capture affected white matter in the brain, but miss the areas of crossing fibers due to the simplicity of the model. In this work, we use a novel set of spherical-harmonics rotation invariants indices, recently proposed in the literature. We demonstrate that these 12 invariants capture all the information provided by DTI and, in addition, they capture differences in complex white matter beyond DTI measures. This, combined with the clinical feasibility of the method, paves the way for them to be used as better markers of brain injury.

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