Abstract #3626

Qualitative Comparison of Calculated and Measured Ultra-High b-Value Diffusion-Weighted Images in the Assessment of Clinically Significant Prostate Cancer.

David Bonekamp¹, Christopher Edler¹, Jan Philipp Radtke^1,2, Frederik Bernd Laun³, Markus Hohenfellner², Heinz-Peter Schlemmer¹, and Tristan Anselm Kuder⁴

¹Radiology, German Cancer Research Center, Heidelberg, Germany, ²Urology, University Hospital Heidelberg, Heidelberg, Germany, ³MR Physics, University Hospital Erlangen, Erlangen, Germany, ⁴Medical Physics, German Cancer Research Center, Heidelberg, Germany

To qualitatively compare measured and calculated ultra-high b-value (UHB, b-value up to 4000 s/mm2) DWI for detection of clinically significant prostate cancer. UHB-DWI was acquired in 55 patients at 3T in addition to standard DWI (S-DWI) extrapolated to UHB b-values. Two raters R1 and R2 independently assessed DWI and ADC in combination with T2w images. Lesion visibility was best on ultra-high b-value images monoexponentially extrapolated (ME-DWI) from S-DWI and equal on S- and UHB-ADC. The experienced rater was better able to adapt the improved lesion visibility on ME-DWI into the lesion detection task and utilized it for superior predictive performance.

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