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Abstract #3626

Qualitative Comparison of Calculated and Measured Ultra-High b-Value Diffusion-Weighted Images in the Assessment of Clinically Significant Prostate Cancer.

David Bonekamp1, Christopher Edler1, Jan Philipp Radtke1,2, Frederik Bernd Laun3, Markus Hohenfellner2, Heinz-Peter Schlemmer1, and Tristan Anselm Kuder4

1Radiology, German Cancer Research Center, Heidelberg, Germany, 2Urology, University Hospital Heidelberg, Heidelberg, Germany, 3MR Physics, University Hospital Erlangen, Erlangen, Germany, 4Medical Physics, German Cancer Research Center, Heidelberg, Germany

To qualitatively compare measured and calculated ultra-high b-value (UHB, b-value up to 4000 s/mm2) DWI for detection of clinically significant prostate cancer. UHB-DWI was acquired in 55 patients at 3T in addition to standard DWI (S-DWI) extrapolated to UHB b-values. Two raters R1 and R2 independently assessed DWI and ADC in combination with T2w images. Lesion visibility was best on ultra-high b-value images monoexponentially extrapolated (ME-DWI) from S-DWI and equal on S- and UHB-ADC. The experienced rater was better able to adapt the improved lesion visibility on ME-DWI into the lesion detection task and utilized it for superior predictive performance.

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