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Abstract #3646

Kärger Model Difficulties for In Vivo DWI

Catherine L Lian1,2, Brendan Moloney2, Eric M Baker2, Greg Wilson3, Erin W Gilbert4, Thomas M Barbara2, Charles S Springer2, and Xin Li2

1Westview High School, Portland, OR, United States, 2Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 3Home, Mill Creek, WA, United States, 4Surgery, Oregon Health & Science University, Portland, OR, United States

Although it is well known that diffusion-weighted imaging (DWI) is sensitive to in vivo trans-membrane water-exchange, quantitative interpretation of the diffusion b-space decay remains difficult. Using random-walk simulated DWI data, this study investigates the feasibility and reliability in studying the water exchange effects with a multi-exponential fitting approach on DWI data.

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